Pete Savage lab research, UChicago

Molecular Mechanisms of Cancer

Program Leaders: Suzanne Conzen, MD, and Kay Macleod, PhD

The Molecular Mechanisms of Cancer Program focuses on determining the basic cell signaling and gene expression mechanisms that underlie malignancy. The program brings together 47 basic and translational investigators from 13 departments with a wealth of experience in cancer biology, chemistry, cell signaling, systems biology, developmental biology, and drug discovery.

The key research themes of the Molecular Mechanisms of Cancer Program include:

  • Uncover how gene expression is controlled through context-specific regulation and epigenetics (DNA and protein modifications that change gene expression without altering DNA sequence);
  • Determine the cellular mechanisms underlying altered cell growth, including proliferation, death, and metabolism; and
  • Understand the multifaceted mechanisms leading to cancer metastases or spread to distant sites.
  • Current Members

    Nishant Agrawal, MD
    Lev Becker, PhD
    Eric Beyer, MD, PhD
    Jason Cheng, MD, PhD
    Suzanne Conzen, MD
    Jill De Jong, MD
    Bryan Dickinson, PhD
    Wei Du, PhD
    Nickolai Dulin, PhD
    Lucy Godley, MD, PhD
    Geoffrey Greene, PhD
    Tong-Chuan He, MD, PhD
    Yu Ying He, PhD
    Akira Imamoto, PhD
    Jessica Kandel, MD
    Barbara Kee, PhD
    Anthony Kossiakoff, PhD
    Stephen Kron, MD, PhD
    Bruce Lahn, PhD
    Michelle Le Beau, PhD
    Ernst Lengyel, MD, PhD
    Anning Lin, PhD
    Hue Luu, MD
    Kay Macleod, PhD
    Megan McNerney, MD, PhD
    Raymond Moellering, PhD
    Gokhan Mutlu, MD
    Marcelo Nobrega, MD, PhD
    Tao Pan, PhD
    Sean Pitroda, MD
    Glenn Randall, PhD
    Ilaria Rebay, PhD
    Carrie Rinker-Schaeffer, PhD
    Marsha Rosner, PhD
    Benoit Roux, PhD
    Alex Ruthenburg, PhD
    Michael Spiotto, MD, PhD
    Wei-Jen Tang, PhD
    Michael Thirman, MD
    Donald Vander Griend, PhD
    Samuel Volchenboum, MD, PhD
    Kevin White, PhD
    Amittha Wickrema, PhD
    Chung-I Wu, PhD
    Xiaoyang Wu, PhD
    Yingming Zhao, PhD