There are many factors that can increase a person’s risk of developing certain cancers including age, lifestyle, and genetics, to name a few. Though it is not possible to identify the exact cause for most cancers, scientists continue to identify risk factors that may play a role. At the University of Chicago Medicine, the Com- prehensive Cancer Risk and Prevention Clinic is dedicated to identifying and caring for individuals who have an increased risk of cancer due to family history, or medical and genetic factors. Founded in 1992, the Clinic was the first in Illinois to provide comprehensive preventative services and is cur- rently led by Olufunmilayo Olopade, MBBS, FACP, Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics, Sonia Kupfer, MD, assistant professor of medicine, and Jane Churpek, MD, assistant professor of medicine. Today, more than 3,000 patients are closely monitored for the very earliest signs of breast, ovarian, and gastrointestinal cancers. These patients include both cancer survivors with a high risk of recurrence and individuals with a family history or personal genetic profile that makes them more vulnerable to the disease. Olopade is an expert in breast cancer risk, and has identified breast cancer mutations in African fami- lies that are distinct from those found in Caucasian women, transforming screening and treatment in Africa and beyond. Her research team also made the seminal discovery that the majority of African women diagnosed with breast cancer have triple- negative tumors (a type of breast cancer that is aggressive and hard to treat). Kupfer researches colon cancer risk in individuals with inflammatory bowel disease and in African- American families with inherited predisposition. In one study,1 she and her colleagues character- ized the specific mutations and risk for colorectal cancer in African Americans with a genetic condi- tion called Lynch syndrome, identifying new muta- tions and cancer risk factors for this population. Churpek and Lucy Godley, MD, PhD, professor of medicine, offer personalized risk assessment to Comprehensive Cancer Risk and Prevention Clinic Genetic testing is not required for cancer risk counseling and assessment. However, in some cases results from a genetic test may help patients and their phy­ sicians make important decisions about care. Undergoing genetic testing is the personal choice of each patient. Genetic testing and counseling may be helpful if: The patient or a close adult relative is diagnosed at a young age (less than 50 years old)