Letter from the Director Innovation is defined as the introduction of something new or a new idea, method, or device. It’s applying fresh solutions to difficult problems. In cancer research especially, innovation is the key to making real progress in the name of reducing cancer’s devastating effects. Innovation is what allows research- ers at the University of Chicago Medicine Comprehensive Cancer Center to push the boundaries of discovery and blaze new paths for better care and outcomes for cancer patients. The 2017 annual report highlights some of the ways in which we are using innovation to advance discovery and clinical practice. The use of new technology and methods has broadened the realm of what is possible in cancer research. From developing novel chemical probes to better monitor and disrupt signaling within cancer cells to launching first-of-its-kind population studies to uncover fac- tors that contribute to the risk of developing cancer, our research- ers are better understanding how cancer develops and discovering novel ways to prevent or treat it. Other new advances, made possi- ble by state-of-the-art equipment, such as the new cyclotron—the only particle accelerator for devel- oping imaging and therapeutic compounds in an academic med- ical institution in Illinois—and the most cutting-edge gene panels for genetic profiling of tumors, are advancing both research and clin- ical care. In this report, we also spotlight new technology- or device-driven treat- ments that are revolutionizing how aggressive cancers, including those that have spread, are being treated. For example, new approaches to cancer surgery and chemother- apy, such as Heated IntraPEritoneal Chemotherapy, have made a sig- nificant impact on patients with mesothelioma or other cancers in the lining of the abdomen. In addition, innovative partner- ships for a new education program aimed at enhancing diversity in the cancer research workforce are furthering our mission of training the next generation of cancer researchers. Innovation touches every aspect of cancer research and has the power to change healthcare and the lives of those who receive it. The latest innovations at the University of Chicago are changing how cancer research and care take place in the world. These accomplishments, fueled by innovation, would not be possi- ble without continued investment and philanthropy through the University of Chicago Campaign: Inquiry and Impact Janet D. Rowley Discovery Fund. We are grateful for our supporters who enable us to chart a new path for- ward for cancer prevention, diag- nosis, treatment, and survivorship. With sincere gratitude, Michelle M. Le Beau, PhD Arthur and Marian Edelstein Professor of Medicine Director, the University of Chicago Medicine Comprehensive Cancer Center 2 Powered by Innovation