The goal of the Analytic and Informatics Core (AIC) is to work with investigators of each SPORE research project and personnel of the Biospecimen, Pathology, and Genotyping Core to provide an integrated data management system (TraM) and to serve as a resource for the design of experiments and clinical trials, development of innovative statistical methodology, statistical analysis, and publishing translational research generated through the Breast SPORE program. The specific aims of the AIC are to:
Aim 1: Complete the development of SPORE databases, including the development of systems to enhance the accuracy and completeness of project data and facilitate the sharing of data and results among SPORE investigators. The systems will link clinical, tissue, and laboratory data in a relational schema and include a web application interface that allows researchers to access databases, perform queries, and export data for statistical analysis.
Aim 2: Provide statistical expertise in designing and conducting laboratory experiments, clinical trials, and genetic and epidemiologic studies.
Aim 3: Perform statistical analyses and assist in the interpretation of study findings, summarization of results, and preparation of manuscripts for publication.
Aim 4: Conduct methodological research to provide research infrastructure for SPORE projects. The AIC will collaborate on the extension of HapMap information to members of CEPH pedigrees not included in the HapMap through use of linkage mapping information on all pedigree members. This research project will substantially improve the power and resolution of Project 4, as well as provide a public resource with phenotype information on CEPH cell lines for use by other investigators.
Aim 5: Collaborate and assist all project investigators with the publication of scientific results.