In This Section

A Comprehensive Cancer Center Designated by the National Cancer Institute

Research Program

Pharmacogenomics and Experimental Therapeutics

Program Leaders: Walter Stadler, MD, and M. Eileen Dolan, PhD

The Pharmacogenomics and Experimental Therapeutics Program is a cohesive, integrated program with 47 members representing nine departments. The program has a long-standing focus on drug development at all phases of clinical testing and a strong pharmacogenetic component. The types of trials range from preclinical development, to investigator-initiated Phase I clinical trials, to Phase II trials in the regional Phase II network, to Phase III studies with Cancer and Leukemia Group B (CALGB).

The scientific goals are to:

  • Pursue a broad program of preclinical, translational, and clinical research in pharmacogenomic, molecular target, and biomarker research;
  • Foster interactions between basic and clinical investigators that will result in innovative and effective therapies; and
  • Integrate new drugs into the development of multimodality therapies for patients with advanced solid tumors.

The translational nature of much of the work emanating from this program, the coordinating center role the University of Chicago Medicine Comprehensive Cancer Center plays for multi-institutional studies, and the leadership role assumed by many program faculty in studies conducted by national clinical cooperative groups, illustrates the impact of this program in developing new therapies for oncology.

Program Members:

Department of Chemistry
Chuan He, PhD
Wenbin Lin, PhD

Department of Health Studies
Theodore Karrison, PhD
Ronald Thisted, PhD

Department of Medicine
Daniel Catenacci, MD
M. Eileen Dolan, PhD
Gini Fleming, MD
Philip Hoffman, MD
R. Stephanie Huang, PhD
Hedy Kindler, MD
Michael Maitland, MD, PhD
Yusuke Nakamura, MD, PhD
Chadi Nabhan, MD
Rita Nanda, MD
Peter H. O'Donnell, MD
Mark Ratain, MD
Tanguy Seiwert, MD
Manish Sharma, MD
Walter Stadler, MD
Russell Szmulewitz, MD
Victoria Villaflor, MD
Everett Vokes, MD

Department of Neurology
M. Kelly Nicholas, MD, PhD

Department of Obstetrics & Gynecology
S. Diane Yamada, MD

Department of Pathology
John Hart, MD

Department of Pediatrics
Susan Cohn, MD
Navin Pinto, MD
Charles Rubin, MD

Department of Radiation and Cellular Oncology
Douglas Bishop, PhD
Steven Chmura, MD, PhD
Philip Connell, MD
Daniel Haraf, MD, MS
Ralph Weichselbaum, MD

Department of Surgery
Elizabeth Blair, MD
David Chang, MD
Scott Eggener, MD
Mark Ferguson, MD
Rex Haydon, MD, PhD
Edwin Kaplan, MD
Alexander Langerman, MD
Louis Portugal, MD
Mitchell Posner, MD
Kevin Roggin, MD
Arieh Shalhav, MD
David Song, MD, MBA
Gary Steinberg, MD
Bakhtiar Yamini, MD

Comprehensive Cancer Center
Marcy List, PhD