In This Section

A Comprehensive Cancer Center Designated by the National Cancer Institute

Research Program

Molecular Mechanisms of Cancer

Program Leaders: Suzanne Conzen, MD, and Kay Macleod, PhD

The Molecular Mechanisms of Cancer Program focuses on determining the basic cell signaling and gene expression mechanisms that underlie malignancy. The program brings together 36 basic and translational investigators from 10 departments with a wealth of experience in chemistry, cell signaling, systems biology, developmental biology, and drug discovery. These investigators are dedicated to discovering mechanisms of abnormal cell growth that could lead to innovative anti-cancer treatments.

The research aims of the Molecular Mechanisms of Cancer Program are to:

  • Clarify the molecular mechanisms of organ-specific and tumor cell type-specific gene expression;
  • Determine the cellular mechanisms underlying cell growth/division and cell survival/death;
  • Understand the multifaceted mechanisms leading to cancer metastases;
  • Use large-scale, high-throughput and systems biology approaches, as well as genetic evolutionary approaches to understand cancer biology; and
  • Discover novel developmental pathways relevant to cancer cell signaling.

In recent years, members of the Molecular Mechanisms of Cancer Program have enhanced the translational components of the program and have fostered collaborations between cancer biologists, chemists, and imaging scientists. The goal of these initiatives is to identify potential targets and signaling pathways involved in cancer and to facilitate the testing of small molecule inhibitors of these targets and/or pathways.

Program Members:

Ben May Department for Cancer Research
Wei Du, PhD
Geoffrey Greene, PhD
Akira Imamoto, PhD
Shutsung Liao, PhD
Anning Lin, PhD
Kay Macleod, PhD
Ilaria Rebay, PhD
Marsha Rosner, PhD
Wei-Jen Tang, PhD
Xiaoyang Wu, PhD
Yingming Zhao, PhD

Department of Biochemistry and Molecular Biology
Shohei Koide, PhD
Benoit Roux, PhD

Department of Ecology and Evolutionary Biology
Chung-I Wu, PhD

Department of Human Genetics
Bruce Lahn, PhD
Marcelo Nobrega, MD, PhD
Kevin White, PhD

Department of Medicine
David Boone, PhD, MS
Suzanne Conzen, MD
Nickolai Dulin, PhD
Yu Ying He, PhD
Deborah Lang, PhD
Ravi Salgia, MD, PhD
Julian Solway, MD
David Vanderweele, MD, PhD

Department of Molecular Genetics and Cell Biology
Stephen Kron, MD, PhD
Bernard Roizman, ScD

Department of Obstetrics & Gynecology
Ernst Lengyel, MD, PhD

Department of Pediatrics
Eric C. Beyer, MD, PhD
Samuel Volchenboum, MD, PhD, MS

Department of Radiation and Cellular Oncology
Michael Spiotto, MD, PhD

Department of Surgery
Tong-Chuan He, MD, PhD
Jessica Kandel, MD
Hue Luu, MD
Carrie Rinker-Schaeffer, PhD
Donald Vander Griend, PhD

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