Michelle M. Le Beau, PhD, Arthur and Marian Edelstein Professor of Medicine, was appointed director of the University of Chicago Medicine Comprehensive Cancer Center in April 2004. Dr. Le Beau is particularly well qualified to enhance translational and interdisciplinary research at the Comprehensive Cancer Center, in view of her impressive record of converting fundamental laboratory findings into highly relevant advances in the diagnosis and treatment of patients with hematological malignant diseases.
Dr. Le Beau received her PhD in pathology and genetics in 1981 at the University of Illinois. She subsequently obtained post-doctoral training at The University of Chicago Medicine under the mentorship of Janet D. Rowley, MD, DSc, the Blum-Riese Distinguished Service Professor of Medicine, and was appointed to the faculty in 1986, rising to tenured professor in 1997. In her capacity as director of the Cancer Cytogenetics Laboratory, Dr. Le Beau directs a cancer diagnostics laboratory, which performs cytogenetic analysis of leukemias, lymphomas, and solid tumors. She is board-certified in clinical cytogenetics by the American Board of Medical Genetics. Active in many leadership roles, she preivously served as the vice president/president elect for the Association of American Cancer Institutes. She is currently a member of the Board of Directors of the American Association for Cancer Research. the Leukemia and Lymphoma Society, and the American Society of Hematology.
Dr. Le Beau has been a leader in identifying the recurring cytogenetic abnormalities in hematological malignant diseases, in defining the clinical, morphological, and cytogenetic subsets of leukemias and lymphomas, and in identifying the genetic pathways that lead to myeloid leukemias. Much of her work has focused on therapy-related acute myeloid leukemia (t-AML), and she is the principal investigator of a National Cancer Institute (NCI)-sponsored Program Project (P01) grant examining the etiology of t-AML. Dr. Le Beau has a distinguished record of achievement in basic and translational research. Her entire career has focused on cancer research, and she has extensive experience in building interdisciplinary research programs, developing the careers of young scientists, and overseeing the administration of large peer-reviewed grants amongst other responsibilities.
Walter Stadler, MD, Fred C. Buffet Professor of Medicine and Surgery, chief of the Section of Hematology/Oncology associate dean for clinical research, and director of the genitourinary program, is the deputy director of the Comprehensive Cancer Center.
Dr. Stadler joined the faculty more than 20 years ago and focuses his research on innovative treatments
for urological cancers as well as clinical trial design. He concentrates on the use of chemotherapy, immunotherapy, anti-angiogenic therapy, and molecularly targeted therapy for patients with locally advanced or metastatic disease. His research focuses on the development of new treatments for these urological cancers. Dr. Stadler's recent research includes development of molecular and imaging markers for predicting response to various anti-cancer therapies.
As deputy director, Dr. Stadler assists and advises the director with strategic planning, general administration of the Comprehensive Cancer Center, and implementation of specific programs. He also participates in institutional long-range planning and maintains contact with members of the External and Internal Advisory Committees.
Marcy A. List, PhD, leads the Comprehensive Cancer Center administrative unit. She has served in this capacity for a decade and brings extensive experience in cancer center administration and population research.
She joined UChicago Medicine faculty in 1992 as a research associate (associate professor) in the Department of Medicine, Section of Hematology/Oncology, where, for over a decade she was involved in cancer control research, specifically quality of life in head and neck cancer.
As associate director for administration, Dr. List has broad oversight for administrative and fiscal management of the Comprehensive Cancer Center, including accounting and financial transactions, personnel, IT infrastructure to support clinical trials operations, pre- and post-awards for the Cancer Center Support Grant (CCSG) and multiple interdepartmental grants, Cancer Center public relations and publications, and philanthropic activities. She is the scientific director for the Cancer Clinical Trials Office (CCTO) and oversees the Protocol Reviewing and Monitoring System (PRMS). In addition, she participates in strategic planning activities and implementation of plans for programmatic growth.
Habibul Ahsan, MBBS, MMedSc, Louis Block Professor of Health Studies, Medicine, and Human Genetics, is the associate director for population research at the Comprehensive Cancer Center and senior co-leader of the Cancer Prevention and Control Program.
He works closely with the director and the other program leaders in shaping and refining the population research programmatic goals and activities within the context of the overall cancer center mission. Specifically, Dr. Ahsan leads the faculty recruitment and pilot research programs for the population research division to augment the existing programmatic strengths and bridge both intra- and inter-programmatic interactions.
His research focus is on the effects of environmental agents and their interplay with genetic and other host factors in the development of cancer and other disorders.
Dr. Ahsan has been conducting a series of large epidemiological and clinical studies in Bangladesh to examine the health effects of arsenic exposure and evaluating strategies for their prevention. He also led a number of studies in the U.S. examining the role of genetic susceptibility and its interactions with environmental factors in the development of breast and other cancers.
M. Eileen Dolan, PhD, professor of medicine, chair of the committee on clinical pharmacology and pharmacogenomics, and program co-leader of the Comprehensive Cancer Center pharmacogenomics and experimental therapeutics program, is the Comprehensive Cancer Center associate director for education.
In this role, Dr. Dolan expands, integrates and coordinates all cancer-related educational efforts in the Comprehensive Cancer Center. She coordinates a summer research program for high school and undergraduate students to perform cancer research and organizes “science boot camp” for these students. She organizes bi-monthly seminar series for faculty and students. She coordinates new cancer-related educational opportunities for graduate students and fellows.
Dr. Dolan is considered a leader in pharmacogenomics of anticancer agents. She is known for developing cell-based methods to identify genetic variants contributing to chemotherapeutic induced toxicity. Her laboratory lead the way in using International HapMap lymphoblastoid cell lines (LCLs) to demonstrate that chemotherapeutic induced cytotoxicity is a heritable trait and demonstrated differences in gene expression and sensitivity to chemotherapy in LCLs derived from individuals of European, African, African American and Asian descent. More recently, her laboratory is employing induced pluripotent stem cell derived neuronal cells to evaluate chemotherapeutic induced neuropathy, the most common non-hematologic adverse effect of chemotherapy. She is involved in a number of clinical genome wide association studies to identify and functionally validate genetic variants/genes contributing to chemotherapeutic-induced toxicities.
Geoffrey Greene, PhD, is the Virginia and D.K. Ludwig Professor, chair of The Ben May Department for Cancer Research, co-director of the Ludwig Center for Metastasis, andassociate director for basic sciences at the Comprehensive Cancer Center.
Dr. Greene oversees the implementation, organization, and activities of the Comprehensive Cancer Center research programs and core facilities that support these programs. He assists and advises the Comprehensive Cancer Center director on strategic and operational decisions and participates in philanthropic fundraising efforts, especially with The University of Chicago Cancer Research Foundation (UCCRF).
Dr. Greene is internationally recognized for his many contributions to the field of steroid hormone action and breast cancer. His contributions have improved not only our understanding of the nature and function of steroid receptors, but also their measurement and utility in cancer. In addition, his ongoing structural studies have helped define novel selective estrogen receptor modulators (SERMs) that may be suitable for breast and uterine cancer prevention in women, as well as for use in promoting many of the desirable effects of estrogen, such as maintenance of bone density and cardiovascular function, while reducing undesirable side effects.
Karen Kim, MD, professor of medicine, is the director of the Office of Community Engagement and Cancer Disparities (OCECD). She specializes in the prevention, screening, and early detection of colorectal cancer, hepatitis B, and women's health issues–particularly functional bowel diseases. She is skilled in the assessment of hereditary colon cancer syndromes and colon cancer risk in families.
Dr. Kim's research explores chemoprevention for colon cancer and screening methods for populations with average and high risk. Her research interests include underserved and minority populations, understanding health disparities, cultural competency, and cancer prevention. She has also studied the education and awareness of hepatitis B in Asian Americans through screening, advocacy, treatment, and immunization for liver cancer prevention.
Mark Ratain, MD, Leon O. Jacobson Professor of Medicine and director of the Center for Personalized Therapeutics, is the associate director for clinical sciences at the Comprehensive Cancer Center and leader of the Pharmacology Core Facility.
Dr. Ratain oversees the implementation, organization, and activities of the programs and core facilities that support clinical research. He advises the Comprehensive Cancer Center director on strategic planning and operational and budgetary issues in the area of clinical research. Dr. Ratain also serves as chair of the Clinical Research Advisory Committee (CRAC), which meets quarterly to review operations and policy related to clinical research, including the CCTO and PRMS.
Dr. Ratain's research interests are in the pharmacogenetics of anticancer agents and Phase I and Phase II drug studies. Pharmacogenetics is the study of how genetic variation among individuals contributes to differences in the way they respond to medicine. Dr. Ratain's research is focused on the metabolism of specific anticancer agents. He has demonstrated the critical importance of genetic variants in determining variability in the pharmacokinetics and toxicity of certain anticancer drugs. His research has become a model for understanding variability in response to newer targeted drugs.
Susan Cohn, MD, professor of pediatrics, is dean of clinical research and an executive commmittee member of the Comprehensive Cancer Center She is a highly respected expert in pediatric cancers and blood diseases. She is a leading authority on neuroblastoma, a cancer of nerve cells, and the most common type of cancer found in infants.
Dr. Cohn is actively researching several aspects of neuroblastoma. She is one of the few pediatric oncologists in the United States who is conducting Phase I clinical trials of promising treatments for the disease. Her research has received generous support from the National Institutes of Health/National Cancer Institute and the National Institute of Neurological Disorders and Stroke.
In recognition of her extensive expertise in pediatric clinical research, Dr. Cohn was selected to be the first section chief of clinical sciences at the University of Chicago Department of Pediatrics.
John Cunningham, MD, is the Donald N. Pritzker Professor of Pediatrics and an executive committee member of the Comprehensive Cancer Center. He also serves as chair of the Department of Pediatrics, and Physician-in-Chief of the University of Chicago Medicine Comer Children’s Hospital. Dr. Cunningham is an internationally known expert in the treatment and research of childhood cancers and blood diseases. He has particular expertise in treating leukemia, lymphoma, immunodeficiencies, sickle cell disease and thalassemia. He is a recognized leader in the field of pediatric stem cell transplantation, and has developed novel uses for this life-saving treatment.
An active researcher, Dr. Cunningham is studying the biology and therapy of hemoglobinopathies, hematopoiesis and the leukemia stem cell, transcriptional mechanisms operative during the development of vertebrate organisms, and the development of clinical trials for the treatment of leukemia and genetic diseases. Dr. Cunningham is a member of the scientific council of the American Cancer Society, and a member of the editorial board of The Oncologist.
Mitchell Posner, MD, is the Thomas D. Jones Professor of Surgery and Physician-in-Chief of the Comprehensive Cancer Center. He also serves as chief of the Section of General Surgery and Surgical Oncology. With a reputation earned as a leading authority in the management of upper gastrointestinal cancers, Dr. Posner couples his skill as a cancer surgeon with a commitment to multidisciplinary care, providing his patients with optimal outcomes.
Dr. Posner’s work goes beyond the operating room. In the lab, he focuses on the molecular basis of malignancies, which has enabled him to design and guide groundbreaking clinical trials for cancers of the pancreas, esophagus, colon, stomach, rectum, and liver. With more than 30 years of experience, he has won dozens of awards and published 200 articles, abstracts, and book chapters.
Marsha Rosner, PhD, is the Charles B. Huggins Professor and an executive committee member of the Comprehensive Cancer Center. Dr. Rosner received her bachelor's degree in biochemistry from Harvard University and her PhD degree in biochemistry from the Massachusetts Institute of Technology. She then stayed at MIT to pursue postdoctoral work as a fellow of the American Cancer Society in the laboratory of Dr. Phillip Robbins. In 1982, she assumed her first faculty position as an Assistant Professor in the Dept. of Applied Biological Sciences at MIT.
Dr. Rosner joined the University of Chicago faculty as an Associate Professor in 1987 and was promoted to Full Professor in 1994. In 1994 she was named the first Chair of the Committee on Cancer Biology and built a degree-granting graduate program leading to the PhD in Cancer Biology. Under Dr. Rosner's leadership, the Committee on Cancer Biology has become one of the most successful graduate programs within the Division of Biological Sciences at the University of Chicago.
An internationally recognized authority in the field of signal transduction, Dr. Rosner has had a longstanding interest in elucidating the mechanisms by which growth factors promote the growth, differentiation or death of cells.
Mary Ellen Connellan, MA, is the executive director for The University of Chicago Cancer Research Foundation (UCCRF). Connellan has more than 25 years experience in fundraising. She began her professional career in sales for a national telecommunication company. She also served for 16 years as a volunteer participating in all aspects of event-based fundraising. Since September 2000, she has overseen the numerous philanthropic activities of the UCCRF.
As the executive director, she works with individuals, foundations, corporations, and the boards of the foundation in their efforts to support basic and clinical research programs related to the causes, diagnosis, treatment and prevention of cancer at the Comprehensive Cancer Center. Connellan is a member of the National Association of Cancer Center Development Officers (NACCDO) Network.
Crystal Senesac, MBA, is the University of Chicago Medicine Comprehensive Cancer Center director for marketing and communications. As director for marketing and communications, Crystal fulfills a key integrated role in the strategic planning and implementation of marketing and communication initiatives, as related to both research and clinical programs. She works with senior Comprehensive Cancer Center leadership as well as the University of Chicago Medicine (UCM) and BSD marketing departments to advance the Comprehensive Cancer Center mission.
Prior to joining the Comprehensive Cancer Center, Crystal was a marketing manager for the University of Chicago Medicine, specifically for the orthopedics, digestive disease and interventional endoscopy service lines, since 2013.
Rajan Gopalakrishnan, MS, is the director for informatics and information technology (IT) at the University of Chicago Medicine Comprehensive Cancer Center. Rajan joined in May 2011 with 16 years experience in healthcare and public health IT consulting where he worked with several large regional hospital systems and state and public health organizations.
As the director for informatics, Rajan is responsible for the design, maintenance, upkeep of all informatics and IT capabilities within the Cancer Center. In addition, Rajan participates in setting future strategy and the roadmap for cancer informatics functions that will provide cutting-edge support for Comprehensive Cancer Center researchers and staff. Rajan is a member of the American Medical Informatics Association (AMIA) and likes to pursue interesting developments in public health informatics within the cancer domain.
Kathleen Goss, PhD, is the senior science writer and director for strategic partnerships at the University of Chicago Medicine Comprehensive Cancer Center. Dr. Goss brings her expertise in cancer biology to the communications team in the Cancer Center and enhances the relationships with partnering institutions and cancer organizations. She joined the University of Chicago Department of Surgery faculty in 2007 after postdoctoral training and starting her laboratory at the University of Cincinnati.
Apart from her research program in the molecular events driving colorectal and breast cancer, Dr. Goss has been actively engaged in graduate, medical, and undergraduate education at the University of Chicago and strongly committed to cancer outreach and advocacy in the community.
Maria Reyes, MBA, is the business manager for the University of Chicago Medicine Comprehensive Cancer Center and has over 15 years of specialized experience in office management, supervision, human relations, auditing, accounting, budgeting, and grant and contract administration. She collaborates closely with the Biological Sciences Division (BSD), University Research Administration, and Financial Services. Maria is a member of the BSD Post Award Working Group (PAWG) committee, and also serves as the lead for the Center Research Administration subgroup. She was also invited by the Associate Vice President for Research Administration to be a member of the newly formed Research Administration Leadership (RAL) team.
Maria has worked for the Comprehensive Cancer Center since 2001 and manages the daily operations, primarily in the areas of finance, purchasing, grant, facilities, human resources and support services management. Maria has extensive knowledge in the management of large, interdisciplinary, multi-institutional federal and non-federal grants and directly supervises the pre-award and post-award administration teams in the center.
Amanda Spratt, BS, CCRP, is the director for clinical research operations and technical director of the University of Chicago Medicine Comprehensive Cancer Center Clinical Trials Office (CCTO). Amanda joined the Comprehensive Cancer Center in October 2004. She is responsible for the day-to-day administrative oversight of office operations and staff, including hiring and training of new staff, and developing, updating and overseeing implementation of Standard Operating Procedures for all regulatory services. She serves as a resource to both her staff and clinical investigators in issues of clinical research operations, and federal and institutional regulations, and is responsible for the coordination of continuing education workshops.