Alexander Varshavsky, PhD
California Institute of Technology
Dr. Varshavsky has made significant contributions to cancer research. His most notable discovery was uncovering the physiological functions of the regulatory protein ubiquitin, which plays an essential role in the cell cycle, DNA repair, and stress responses. Dr. Varshavsky also identified the first degradation signals that target proteins for ubiquitin-dependent proteolysis (breakdown), including the N-end rule of protein degradation.
Ubiquitin, the N-end Rule, and Regulated Protein Degradation