Each year, we strive to make our impact greater by embracing change and pursuing innovation. This year is no exception. From planning for a new dedi- cated cancer hospital for adults to adding accomplished research- ers to our team, we are preparing for a future that is evolving more rapidly than ever. Immunotherapy—the focus of this issue—embodies the changing world of cancer treatment. In the past decade, the notion that we could harness the body’s immune system to fight cancer evolved from an idea into a reality. Today, immunotherapies are helping patients live longer and providing hope for those who had little. Our researchers continue to lead the immunotherapy revolution through basic research, which aims to improve the efficacy of current treatments, and clinical trials testing new and promising therapies. This issue provides a look at our past and future contributions to the field. In this issue, you will also find examples of our most recent research breakthroughs, new faculty, member honors, and clinical trials. If you have visited cancer.uchicago.edu recently, you will notice that we recently redesigned our website. We hope you enjoy the new look and feel, and find it easy to navigate. We encourage you to visit it often as a way to keep up with all our advancements in research, clinical care, education, and community engagement. Thank you for your support, and we hope you have a wonderful summer! Regards, Michelle M. Le Beau, PhD Director, The University of Chicago Medicine Comprehensive Cancer Center; Arthur and Marian Edelstein Professor of Medicine Spring 2017 EXECUTIVE EDITOR Crystal Senesac MANAGING EDITOR AND WRITER Bethany Hubbard SENIOR SCIENCE WRITER Kathleen Goss, PhD CONTRIBUTING WRITERS John Easton Michael McHugh EDITORIAL ADVISORS Michelle Le Beau, PhD Marcy List, PhD PHOTOGRAPHY David Christopher Jean Lachat Perkins+Will DESIGN Pivot Design, Inc. PRINTING G Thomas Partners LLC Pathways to Discovery is a triannual publication of the University of Chicago Medicine Comprehensive Cancer Center. THE UNIVERSITY OF CHICAGO MEDICINE COMPREHENSIVE CANCER CENTER 5841 S. MARYLAND AVE. MC1140, H212 CHICAGO, IL 60637 PHONE 1-773-702-6180 FAX 1-773-702-9311 FEEDBACK@BSD.UCHICAGO.EDU © 2017 The University of Chicago Medicine Comprehensive Cancer Center. All rights reserved. From the Director AT THE FOREFRONT OF CANCER CARE AND DISCOVERY Pathways TO DISCOVERY